Recent research has brought renewed attention to a specific B-vitamin therapy showing promise for some children with autism—but confusion remains around which form of folate actually works and why.
In this video, Dr. Mark Stengler breaks down the science behind cerebral folate deficiency, a condition in which the brain cannot properly receive folate despite normal blood levels. He explains how folate receptor antibodies can interfere with brain development, why common forms like folic acid may be ineffective, and how biologically active forms such as folinic acid (leucovorin) and methylfolate are being used in integrative care.
Dr. Stengler also reviews recent clinical research demonstrating improvements in communication and social interaction in children receiving folinic acid—while emphasizing that autism is complex and best addressed through a comprehensive, individualized treatment plan.
If you’re seeking evidence-based clarity on B-vitamin therapy and autism—without hype or false promises—this video offers a grounded, science-informed perspective worth understanding.
CHAPTERS
00:00 – B Vitamin Therapy for Autism Explained
00:09 – Meet Dr. Mark Stengler: 30+ Years in Functional Medicine
00:21 – The Role of Folate in Brain Function
00:41 – Why Folate Matters for Kids with Autism
01:00 – How Folate Enters the Brain Through Receptors
01:14 – Folate Receptor Autoantibodies and Cerebral Folate Deficiency
01:35 – How CFD Affects Brain Development and Autism Symptoms
01:51 – Choosing the Right Type of Folate Supplement
02:01 – The Problem with Folic Acid in Autism Treatment
02:22 – The MTHFR Gene and Folate Conversion
02:28 – Why Methylfolate and Folinic Acid Work Differently
02:43 – How Folinic Acid (Leucovorin) Bypasses Blocked Receptors
03:02 – FDA Approval of Leucovorin for Cerebral Folate Deficiency
03:17 – 2024 Study: Folinic Acid Improves Communication and Social Skills
03:48 – Folinic Acid Is Not a Cure but a Promising Therapy
04:03 – The Importance of a Comprehensive Autism Treatment Plan
04:17 – Role of Gut Health, Nutrition, and Inflammation
04:33 – Testing for Folate Receptor Antibodies
04:47 – Medical Guidance for Folinic Acid and Leucovorin Use
05:02 – How Methylfolate and Folinic Acid Support Brain Function
05:10 – Addressing Root Biological Causes in Autism
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